Phase transformations in microcrystalline cellulose due to partial dissolution

Silicified microcrystalline cellulose pdf

Dissolution of microcrystalline cellulose in phosphoric acid--molecular changes and kinetics.

In this study, we aimed to dissolve microcrystalline cellulose (MCC) with phosphoric acid to obtain high-quality fermentable saccharides. MCC was directly dissolved in phosphoric acid (the concentration was 83%) for 10 hours at temperatures of 30, 50, and 70 degrees C. The structural changes of MCC were determined in detail with X-ray powder diffraction, solid-state cross-polarization magic ang...

Improvement of Dissolution Properties of Ketoconazole Using a New Excipient (LoxOralTM) in Comparison with Microcrystalline Cellulose

Introduction: Poor aqueous solubility of an active pharmaceutical ingredient (API) is one of the most pressing problems in pharmaceutical R&D, with as many as 90% of new API candidates in this category (Lobmann et al., 2013). Dissolution rate in the gastrointestinal tract is the rate limiting factor for the absorption of many of these drugs (Zimmermann et al., 2009), which may limit their bioav...

Comparison of Dissolution Properties of Piroxicam Using Microcrystalline Cellulose and a New Excipient (LoxOralTM)

Introduction: During the last decade, the trend in drug discovery has increased the number of active pharmaceutical ingredients (APIs) that exhibit high lipophilicity and poor water solubility, also associated with poor dissolution characteristics (Vogt et al., 2008). Dissolution rate in the gastrointestinal tract is the rate limiting factor for the absorption of many of these drugs, which ther...

Partial enzymatic hydrolysis of microcrystalline cellulose in ionic liquids by Trichoderma reesei endoglucanases